The Tiotropium Safety and Performance in Respimat® (TIOSPIR®) Trial: Spirometry Outcomes.

Respir Res · 2015 · PMC4570597 · PMID 26369563

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

Similar to a previous post-hoc analysis [ 18 ], the rate of FVC decline of patients in GOLD Stages I + II showed a trend toward being higher than that in GOLD III + IV patients in this substudy, but this did not reach statistical significance.

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