Clinical Application of Multigene Panels: Challenges of Next-Generation Counseling and Cancer Risk Management.

( 32 ) observed an increased ovarian cancer risk for carriers by a factor of 2.3; however, findings did not reach statistical significance ( 32 ).

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PMS2 , Incidental Finding but Possibly Significant for Management Case 3 is a 30-year-old unaffected woman of Northern European ancestry, self-referred for GCRA due to a family history of multiple cancers that included a paternal aunt who had breast cancer at age 44 and a new primary breast cancer at age 46, who passed away at age 52, a maternal grandmother who had breast cancer in her 60s and died at age 70, and a maternal aunt with ovarian cancer in late 40s who was alive at age 55 (no pathological reports available).

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The laboratory reported that the variant was of “indeterminate significance” and yet that it may increase cancer risk.

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