Association of SNPs in EGR3 and ARC with Schizophrenia Supports a Biological Pathway for Schizophrenia Risk.

PLoS One · 2015 · PMC4608790 · PMID 26474411

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hedged sentences

0.0000

closest p · 0.0× alpha

0.0700

boldest claim

The sentences

highly significantp = 2.353 x 10 −7actually significant

However, combining the EU, AA, and CH groups revealed a highly significant association of ARC SNP rs35900184 (p = 2.353 x 10 −7 ; OR [95% CI] = 1.54 [1.310–1.820]).

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a trend toward significancep = 0.07so close (0.05 < p ≤ 0.1)

In the AA cohort, there were no significant associations between the three EGR3 or the single ARC SNP tested, though the ARC SNP rs1996147 showed a trend toward significance (p = 0.07).

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showed a trendp = 0.07so close (0.05 < p ≤ 0.1)

In the EU group EGR3 SNP rs1877670 showed a trend toward association (p = 0.07), and the ARC SNP rs35900184 revealed a significant association with the schizophrenia diagnosis (p = 0.02).

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nominally significantno p-value reported

rs1996147 demonstrated Δ MAFs of 8.6% in EUs and 5.9% in AAs in our NGS discovery analysis, and showed nominally significant association with bipolar disorder in a study of circadian rhythm genes [ 42 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.