Impact of Diverse Immune Evasion Mechanisms of Cancer Cells on T Cells Engaged by EpCAM/CD3-Bispecific Antibody Construct AMG 110.

PLoS One · 2015 · PMC4624873 · PMID 26510188

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0900

boldest claim

The sentences

a strong trendp = 0.06so close (0.05 < p ≤ 0.1)

Expression of TGF-β induced a 3-fold reduction in the potency of lysis with a strong trend (p = 0.06; N = 5).

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a weak trendp = 0.09so close (0.05 < p ≤ 0.1)

The >4-fold inhibitory effect of Bcl-2 on the EC 50 value of lysis showed a weak trend (p = 0.09; N = 3), and a statistically significant albeit small reduction (see Fig 2C ) in the percentage of lysed cells (p = 0.01; N = 4).

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showed a trendno p-value reported

The impact on the EC 50 value of lysis showed a trend and did not exceed a 7-fold reduction.

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