Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases.

R-naproxen pretreatment of Swiss 3T3 cells for 1 h also showed a trend of dose-dependent inhibition of EGF-stimulated Cdc42 activation, which was maximal at 300 μM drug and comparable to treatment with 10 μM of Cdc42 specific inhibitor CID2950007/ML141 ( Fig 2B ).

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Unlike Rac1 activity, the relatively low levels of Cdc42 activity in Swiss 3T3 cells were more difficult to measure reproducibly via GLISA, and despite many trials the data did not reach statistical significance.

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