Plasma levels of M-CSF are increased in ANCA-associated vasculitides with active nephritis.

M-CSF correlated with clinical and biochemical markers of systemic inflammation and showed a trend towards a higher expression in patients who eventually experienced a disease flare or who did not reach remission 6 months after sample collection.

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Patients with active urinary sediment, significant 24 h proteinuria and typical findings at renal biopsy had also higher M-CSF levels although these findings did not reach statistical significance ( Table 2 ).

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