Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis.

The DTI score, which quantifies the number of VPs per investigated surface area, showed a trend toward higher mean values in the carriers of FLG mutations compared with FLG wild-type subjects at week 0 (427.0 and 336.2, respectively) and after 6 weeks of therapy (296.6 and 224.3, respectively), although the differences did not reach statistical significance (data not shown).

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