Per protocol set analyses demostrated improvements over placebo in the number of days per week with at least one stool having a BSS classification of 6 or 7 and mean weekly score of the worst abdominal pain experienced during the past 24 hours were observed with 60 mg ONO-2952 over the 4-week treatment period but did not achieve significance at a 5% level (P < 0.10).
GTT was longer in the intervention group but this did not reach statistical significance (median 23 vs 51 minutes Mann-Whitney U=1487, p=0.116).
Both dysphagia and regurgitation scores showed highly significant improvement (p< o.oo5) during 3- and 12-mo FU.
It also showed improvement in survival rates in the irrigation group trending towards significance.
Nakamura 1 1 Hyogo College of Medicine, Hyogo, Japan Contact E-mail Address: turuturu@hyo-med.ac.jp Introduction: In Japan and most other developed nations, the prevalence of Crohn’s disease (CD) is on an increasing trend.