As the lowest free dose (3.75 mg/kg) produced very limited and barely significant variations in blood pressure, we feared it would preclude us to demonstrate an in vivo sustained delivery of GSNO.
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In Situ Microparticles Loaded with S-Nitrosoglutathione Protect from Stroke.
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free GSNO ( Fig 9B and 9C ), but the differences between in situ implants and microparticles did not reach statistical significance.
However, when loaded at 30 mg/kg, in situ microparticles and implants flattened the aggregation profile with no transient hyper-aggregability and an inhibitory effect that failed to reach statistical significance.