In the noninfarct area, however, the difference in apoptosis between antagomir and control group hearts only showed a trend towards reduction but did not reach statistical significance ( Figure 4(c) ). qPCR showed that miR-208a silencing in MI also decreased Bax levels at 28 days ( Figure 4(d) ).
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MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves Cardiac Function after Myocardial Infarction.
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