A significant trend towards increased association with gallbladder cancer was observed with potentially higher-risk FEN1-69G > A genotypes (P < 0.001, χ2 trend test) and FEN14150G > T (P < 0.001, χ2 trend test) in gallstone presence but not in gallstone absence (P = 0.81, P = 0.89, respectively).
In contrast, near-significant increases in risk for gallbladder cancer were observed for gallstone presence with the FEN1 -69G > A GA (OR = 2.3, 95% CI = 1.5–3.5) and the FEN14150G > T GT (OR = 3.7, 95% CI = 1.4–9.8), whereas significant increases in association for gallbladder cancer were observed for gallstone presence with the FEN1 -69G > A GG (OR = 6.8, 95% CI = 2.1–28.31) and the FEN14150G > T GG(OR = 7.2, 95% CI = 2.2–20.2).