Bovine Lactoferrin-Induced CCL1 Expression Involves Distinct Receptors in Monocyte-Derived Dendritic Cells and Their Monocyte Precursors.

Although MoDCs exposed to bLF showed a trend towards a higher accumulation of CCL1 mRNA at both time points assessed (4.6 and 5.3 fold increase at 2 and 4 h post treatment, respectively), the differences did not reach statistical significance ( Figure 2 B). 2.2. bLF-Mediated Up-Modulation of CCL1 Secretion Requires Different Receptors in Mo and MoDCs LF can interact, specifically or by virtue of its highly cationic nature, with a variety of cell determinants with different grade of specificity, including molecules involved in pathogen recognition such as DC-SIGN, CD14, TLR2 and TLR4 [ 4 , 5 , 27 ].

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