A nested cohort study of 6,248 early breast cancer patients treated in neoadjuvant and adjuvant chemotherapy trials investigating the prognostic value of chemotherapy-related toxicities.

BMC Med · 2015 · PMC4693418 · PMID 26715442

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.1000

boldest claim

The sentences

showed a trendP = 0.06so close (0.05 < p ≤ 0.1)

Patients with fatigue (grades ≥3) showed a trend towards reduced survival (breast cancer-specific survival: HR = 1.17; 95 % CI, 0.99–1.37; P = 0.06).

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nominally significantP <0.1so close (0.05 < p ≤ 0.1)

Neutropenia, fatigue, anaemia, combined haematological toxicity and constipation were nominally significant ( P <0.1) for either BCSS or RFS (or both) on univariable analysis (Table 2 ).

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