Primary Invasive Squamous Cell Carcinoma of the Nipple.

Another series showed more frequent p53 expression in squamous cell carcinomas with keratoacanthoma like features versus well-differentiated squamous cell carcinomas and keratoacanthomas, but the differences did not reach statistical significance [ 11 ].

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One study showed a significant trend in the proportion of p53 reactivity from keratoacanthomas to poorly differentiated squamous cell carcinomas, although p53 reactivity could not reliably distinguish between keratoacanthoma and well-differentiated squamous cell carcinoma [ 10 ].

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