CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.

4 ) showed a clear trend toward elimination of CTF25s by CUL2 overexpression.

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However, its 35-kDa fragments showed a trend toward accelerated clearance in the presence of CUL2, which was significant at 5 h after CHX treatment in WT TDP-43 ( Fig. 4d ).

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