Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system.

Mice treated weekly with rapamycin but sacrificed on the third day (D3) following treatment had decreased mean phosphorylation of S6 (38% decrease) and AKT (29% decrease), but these results did not reach statistical significance.

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S2A–C), although there was a clear trend toward reduced S6 phosphorylation in pancreatic islets isolated from the D5 intermittent treatment group (Fig.

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