Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance.

The Afmid tm1b/tm1b islets showed a trend of secreting less insulin in response to 500 μM tolbutamide plus 20 mM glucose compared to Afmid +/+ islets ( Fig. 5 B).

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There was no significant difference in total insulin content between the collection of Afmid tm1b/tm1b (mean 1576.1±138.0 pg/ml) and Afmid +/+ (mean 3098.7±518.5 pg/ml) islets, although there was a clear trend towards reduced content in the Afmid tm1b/tm1b .

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