Effect of 3'UTR RET Variants on RET mRNA Secondary Structure and Disease Presentation in Medullary Thyroid Carcinoma.

PLoS One · 2016 · PMC4734678 · PMID 26829565

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did not reach statistical significanceno p-value reported

Interestingly, MTC samples carrying S836S/3’UTR ( GTCAC ) haplotype displayed stronger RET immunostaining than those without these variants, although the difference did not reach statistical significance.

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a strong trendno p-value reported

Remarkably, despite the relative small number of samples, we observed a strong trend towards a significant statistical difference in the RET immunostaining between samples carrying S836S/3’UTR ( GTCAC ) haplotype and those without these variants (392.7 (297–463) vs. 189.5 (152–324), P = 0.054; Fig 4B ).

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