Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease.

Nat Commun · 2016 · PMC4740183 · PMID 26822151

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did not reach statistical significanceno p-value reported

Although similar trends were observed in men, the effect sizes on urea cycle metabolites were not as strong and the associations did not reach statistical significance.

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nominally significantno p-value reported

Rs715 also yielded nominally significant female-specific associations with plasma TMAO and other urea cycle metabolites but not with intermediates, such as homocysteine, methionine, dimethylglycine and sarcosine ( Table 4 ).

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