Double-blind, placebo-controlled pilot trial of L-Leucine-enriched amino-acid mixtures on body composition and physical performance in men and women aged 65-75 years.

Eur J Clin Nutr · 2016 · PMC4744242 · PMID 26081485

Europe PMC DOI

hedged sentences

0.0660

closest p · 1.3× alpha

0.0690

boldest claim

The sentences

almost reached statistical significanceP =0.066so close (0.05 < p ≤ 0.1)

In Group A (standard EAA (20% leucine)), improvements were observed in the 30-CST ( t (7)=−3.211, P =0.015)) and 6-WT ( t (7)=−2.859, P =0.024)); in Group B (modified EAA (40% leucine)), in the 6-WT ( t (7)=−2.659, P =0.032) and in the 30-CST, improvements almost reached statistical significance ( t (7)=−2.173, P =0.066).

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approached significanceP =0.069so close (0.05 < p ≤ 0.1)

Repeated-measures ANOVA revealed no time by participant interaction effects (F(2,22)=0.529, P =0.596); however, main time effects approached significance (F(1, 22)=3.643, P =0.069).

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a significant trendno p-value reported

Despite the fact that LTM gains were lower than previously reported 18 for a standard mixture of EAAs, our data showed a significant trend for greater gains in LTM when subjects were supplemented with a modified mixture enriched with leucine, which was not the case for a standard mixture and a placebo.

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