Incidence Patterns and Trends of non-Central Nervous System Solid Tumours in Children and Adolescents. A Collaborative Study of the Spanish Population Based Cancer Registries.

Among the studied tumours, NB and the group of COET presented a significant trend in children, with APCs of 1.4% and 3.8% respectively.

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In adolescents there were significant increases for all tumours combined (APC=2.7; 95%CI: 1.8-3.6) and for STS, GCT and COET (APCs: 3.2%, 4.4% and 3.5% respectively), while other tumour groups such as hepatic tumours, BT or thyroid carcinomas showed a decreasing trend or no increase.

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Malignant melanoma is also more frequent in girls, similarly to most European countries 27 , although as it happens in our study, gender difference did not reach statistical significance.

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The most recent data available in the United States of America (USA) for children and adolescents 6 shows an increasing trend in incidence for testicular Germ-cell tumours (GCT) and a plateau for bone tumours (BT), neuroblastoma (NB), Wilms tumour (WT), rhabdomyosarcoma (RMS), retinoblastoma and ovarian germ-cell tumours (GCT).

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