Inverse relationship between a genetic risk score of 31 BMI loci and weight change before and after reaching middle age.

A similar trend was observed with annual WHR change but this association did not reach statistical significance ( Supplementary Table 10 ).

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The GRS was associated with 2% decreased odds per risk allele for a weight gain of ⩾10% from baseline to follow-up ( P : 0.034) and showed a trend for 5% decreased odds per GRS quintile and 18% decreased odds when comparing the highest GRS quintile to the lowest GRS quintile from baseline to follow-up ( P : 0.055 and P : 0.087, respectively) ( Figure 2b ).

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