Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons.

Acta Neuropathol Commun · 2016 · PMC4758105 · PMID 26891847

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did not reach statistical significanceno p-value reported

Administration of Type I-NRG1 also showed tendency to extend survival time, however, it did not reach statistical significance (AAV-Type I-NRG1: 161.4 ± 14.0 days; Fig. 4b–e ).

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showed a trendno p-value reported

In addition, the size of remaining motor neurons showed a trend toward enlargement in Type III-NRG1-trasnduced mice compared to GFP-transduced mice (Fig. 5f ).

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