Treatment with selectin blocking antibodies after lengthening contractions of mouse muscle blunts neutrophil accumulation but does not reduce damage.

Another finding contrary to our hypothesis was the observation that macrophage content showed a trend ( P = 0.076) toward a reduction by approximately one‐third in muscles of treated compared with control mice (Fig. 5 ).

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Muscles of mice treated with blocking antibodies showed two‐thirds as many macrophages following lengthening contractions compared with the numbers observed in untreated mice, but the decrease did not reach statistical significance.

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