Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1.

Acta Neuropathol Commun · 2016 · PMC4766719 · PMID 26916443

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a clear trendno p-value reported

Indeed, there was a clear trend for Sorcs1 deficiency to mitigate APP/PSEN1 phenotypes.

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did not reach statistical significanceno p-value reported

When behavior was assessed in the Y-maze, the Sorcs1 -/- mice X APP/PSEN1 cross was associated with significantly impaired learning behavior in the females and trend for worse performance in Sorcs1 -/- and APP/PSEN1 mice, although this did not reach statistical significance.

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