Impaired 2-AG Signaling in Hippocampal Glutamatergic Neurons: Aggravation of Anxiety-Like Behavior and Unaltered Seizure Susceptibility.

Of note, DSI also seems to be influenced in AAV-Glu-MAGL mice, although differences compared to controls did not reach statistical significance ( P =.079) ( Figure 4D ).

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An analogous behavior was found in the light/dark test, where the entries and the time spent in the aversive lit compartment showed a trend towards being reduced in AAV-Glu-MAGL, though without reaching statistical significance (time in lit compartment P =.133, unpaired t test; Figure 5E ; entries in lit compartment P =.060, unpaired t test; Figure 5F ).

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