Tissue-independent and tissue-specific patterns of DNA methylation alteration in cancer.

GPs outside DHSs were generally highly methylated in normal tissue and did not exhibit a clear trend toward either hyper- or hypomethylation in cancer (Fig. 5 a).

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The bivalent GPs located outside DHSs exhibited significantly lower levels of DNAm in normal tissue compared with non-bivalent GPs, resulting in a significant trend toward hypermethylation in cancer, although not as significant as for bivalent GPs located in DHSs (Fig. 5 b).

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