Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice.

In the probe trials, hTau‐A152T (L1) mice tended to take the longest to reach the original platform location and to show the least preference for crossing the target location, although these trends did not reach statistical significance (Fig 6 O–R).

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Old hTau‐A152T (L1) mice showed a trend in the same direction (Fig EV5 A), which was not statistically significant, possibly due to an age‐related decline in nest building capability in the control groups.

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