Interleukin-1 Gene Cluster Polymorphisms and Their Association with Coronary Artery Disease: Separate Evidences from the Largest Case-Control Study amongst North Indians and an Updated Meta-Analysis.

PLoS One · 2016 · PMC4831754 · PMID 27078871

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0700

boldest claim

The sentences

did not reach statistical significancep>0.05actually significant

Significant subgroup differences were observed in the dominant genetic model ( I 2 = 84.8%, P Q = 0.001), while the differences did not reach statistical significance in recessive and allelic models (p>0.05).

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a clear trendp = 0.07so close (0.05 < p ≤ 0.1)

All three genetic models amongst NIA (p≤ 0.04) and the dominant model of AFA (p< 0.01) reached the required statistical significance to confirm association with CAD., On the other hand dominant model amongst AA and allelic model amongst AFA could not reach the desired statistical significance but managed to show a clear trend of association with CAD (p = 0.07 for each).

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