Genetic loci on chromosome 5 are associated with circulating levels of interleukin-5 and eosinophil count in a European population with high risk for cardiovascular disease.

Eosinophil-associated SNPs demonstrated nominally significant associations with progression of IMT-CC max , but only rs2706399 (the G allele of which was previously associated with increased CVD risk [6] ) met the Bonferonni-corrected p for significance (G allele, Beta −0.008, 95%CI (−0.012, −0.004), p = 0.0017, Supplementary Table 3 ).

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The chromosome 14 region included 2 genes, CTAGE5 and FBXO33 and rs4902762 was associated with CTAGE5 expression levels in heart tissue ( p = 0.0073), but this did not reach statistical significance.

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