Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders.

When using linear and logistic mixed effect models, the effect of genotype on primary anxiety disorder response and remission did not reach statistical significance ( Table 3 ; change in CSR: β = −0.06, P = 0.070; remission: OR = 0.55, P = 0.095).

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However, there was a significant effect of genotype on all anxiety diagnoses remission ( Table 3 ; OR = 0.45, P = 0.014), which remained nominally significant when multiple testing corrections were made.

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The effect of genotype on change in primary anxiety disorder symptom severity was suggestive of an improved response for SS genotype carriers but did not reach conventional levels of significance.

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