The second trial also showed a trend towards an improvement in OS, even if it did not reach statistical significance (hazard ratio [HR], 0.86; 95% confidence interval [CI], 0.72 to 1.02; p=0.08). 15 Moreover, a meta-analysis of the two phase III trials showed a significant survival benefit in favor of gemcitabine plus capecitabine (HR, 0.86; 95% CI, 0.75 to 0.98; p=0.02).
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