Polymorphic tandem repeats within gene promoters act as modifiers of gene expression and DNA methylation in humans.

Considering motif lengths with at least 30 occurrences in the set of 1198 TRs that were used in our association analyses, we observed suggestive evidence for a linear relationship between motif length and odds ratio for TRs to act as a QTL (Supplementary Figure S6), although this did not reach statistical significance ( r 2 = 0.54, P = 0.16).

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nominally significant) and (ii) corresponding to a Rho values not significant in any of them (i.e. non-significant), and in each group we generated the distribution of TR:probe distances using bins of 1 kb.

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