Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo.

J Cachexia Sarcopenia Muscle · 2016 · PMC4864181 · PMID 27239406

Europe PMC DOI

hedged sentences

0.0730

closest p · 1.5× alpha

0.0730

boldest claim

The sentences

did not reach statistical significanceP = 0.073so close (0.05 < p ≤ 0.1)

In COPD patients alone, the association of GDF‐15 with RF CSA did not reach statistical significance ( r = −0.298, P = 0.073), but the association with 6 MW was retained ( r = −0.297, P = 0.048).

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did not quite reach statistical significanceno p-value reported

Considering all participants in whom 8‐oxo‐dG measurements were made ( n = 75), there was only a significant univariate relationship between 8‐oxo‐dG levels and BMI (standardized β 0.32, P = 0.005); although there were trends towards an association between 8‐oxo‐dG levels with FFMI ( P = 0.06), RV/TLC ( P = 0.08), and serum GDF‐15 ( P = 0.06), these relationships did not quite reach statistical significance.

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showed a trendno p-value reported

Consistent with this suggestion, the mouse model did not show an equivalent fibre shift but showed a trend towards a reduction in the expression of all MHCs.

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