A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens.

Although decrements due to glucose stimulation failed to reach statistical significance, they were of sufficient magnitude to account, at least potentially, for the accompanying increases in DAG.

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Of the neutral lipid class, TAG was diminished in MIN6 cells in response to glucose ( Figure 1 B), and there was a clear trend toward increases in DAG (significantly so in islets) and less obviously in MAG. 3.2 DAG metabolism in response to glucose DAG was chosen initially for more detailed analysis of the changes in individual species.

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The most obvious effect of glucose on sphingolipid metabolism was a highly significant decrease in ceramide, accompanied in MIN6 cells only by an increase in the glycosylation product monohexosylceramide (MHC).

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