Although the differences in E max at either receptor did not reach statistical significance, the effect was opposite with an increase at the AM 2 receptor and a decrease at the AM 1 receptor.
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Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties.
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C282A binding was unchanged at the AM 1 receptor but showed a trend to be enhanced at the AM 2 receptor ( Fig. 6 ).