Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling.

Clin Kidney J · 2016 · PMC4886906 · PMID 27274832

Europe PMC DOI

hedged sentences

0.0140

closest p · 0.3× alpha

0.0500

boldest claim

The sentences

of marginal significanceP = 0.014actually significant

Although of marginal significance, associations with SLC17A1-17A3 (rs11969868, P = 0.014), ABCG2 (rs2231146, P = 0.029) and ABCC4 (rs4148499, P = 0.049) were also observed among the twins.

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nominally significantP ≤ 0.05actually significant

SNPs on SLC17A3 , SLC22A10 , SLC22A8 , SLC22A11 and ABCC4 were nominally significant at P ≤ 0.05 (Table 1 ).

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highly significantno p-value reported

Conversely, minor alleles on SLC22A8 rs3793961 (P = 0.004) and ABCC4 rs1751003 (P = 0.0001) were associated with lower serum uric acid levels among men only. Discussion The highly significant association of ABCG2 with uric acid in patients with CKD may be one of the first human examples suggesting a likely compensatory intestinal extrusion of uric acid in patients with low GFR.

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