Interleukin 1 Polymorphisms Contribute to Intervertebral Disc Degeneration Risk: A Meta-Analysis.

PLoS One · 2016 · PMC4890740 · PMID 27253397

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a clear trendno p-value reported

Association between IL-1β (+3954C/T) polymorphism and risk of IDD Meta-analysis of the IL-1β (+3954C/T) polymorphism showed no significant association with risk of IDD in any genetic model, nor even a clear trend towards significance (TT versus CC: OR = 1.29, 95% CI: 0.60, 2.77; P heterogeneity = 0.76; CT versus CC: OR = 0.83, 95% CI: 0.58, 1.19; P heterogeneity = 0.81; CT/TT versus CC: OR = 0.90, 95% CI: 0.61, 1.34; P heterogeneity = 0.97; TT versus CC/CT: OR = 1.71, 95% CI: 0.85, 3.46; P heterogeneity = 0.51).

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showed a trendno p-value reported

In contrast, the IL-1β (+3954C/T) polymorphism showed a trend towards increased risk in Caucasians but no association in Asians.

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