Contribution of Heritability and Epigenetic Factors to Skeletal Muscle Mass Variation in United Kingdom Twins.

J Clin Endocrinol Metab · 2016 · PMC4891794 · PMID 27144936

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0100

boldest claim

The sentences

highly significantP < .0001actually significant

This relationship, expressed as R MZ /R DZ (considering bins with positive and significant R DZ ), shows substantial correlation (0.46–0.53, depending on chromosome) and highly significant ( P < .0001) correlation with R repeated ( Figure 2 ).

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nominally significantP < .01actually significant

Testing for DNA methylation association with SMM in 50 discordant MZ twins revealed 36 081 nominally significant results, of which the top-ranked 134 signals ( P < .01 and R repeated > 0.40) were subjected to replication in the sample of 1196 individuals.

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a significant trendno p-value reported

A similar test of the lsBIN distribution in CGIs and shores reveals a significant trend concerning the islands.

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