Genetic risks to nicotine dependence predict negative mood and affect in current non-smokers.

Further constraining the thresholds led to highly significant misfits for both positive and negative factors (positive factors, Δ χ 2 397.1, Δ DF 116, p < 2.2E-16; negative factors, Δ χ 2 444.5, Δ DF 52, p < 2.2E-16).

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rs588765 and rs16969968 showed a trend for the PANAS Nervous at 4 mg (p = 0.006 and 0.007 respectively).

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When the factor loadings were forced to be invariant across the 3 nicotine doses, the change of χ 2 was insignificant for the positive factors (Δ χ 2 10.5, Δ DF 29, p = 0.9993), and the change of χ 2 was nominally significant (Δ χ 2 32.2, Δ DF 18, p = 0.0208) for the negative factors.

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