Consistent with this interpretation, we observed a strong trend towards lower cholesterol content in the livers of mice overexpressing LeXis ( Extended data Fig. 4e ).
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Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis.
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In contrast to the acute LXR agonist studies above, gene expression analysis of LeXis −/− mice maintained on western diet showed a trend toward decreased sterol synthetic gene expression, likely reflecting the marked increased hepatic cholesterol content in this setting ( Extended data Fig. 6d ).