FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation.

Furthermore in the hanging wire grip test requiring strength and coordination the FE65/FE65L1-DKO mice had a significantly lower latency to fall compared to WT mice, while single KOs, which also showed a trend towards a lower latency to fall, were not significantly different from WT mice ( Fig. 1c , p = 0.0001).

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FE65- and FE65L1-KO mice also showed a similar trend for deficits that did not reach statistical significance.

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