Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type Mice.

The test clearly worked as it was supposed to as evident by highly significant differences in glucose levels with time ( p < 0.0001) in all groups analyzed (Figures 3 A–D).

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Our findings indicate that prophylactic vaccination with IAPP and its derivative IAPP 7-19-TT , protects wild-type female mice, but not males, from obesity-induced early mortality, and the derivative showed a strong trend for prolonging the lifespan of Tg females but not males.

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There were no significant differences in the survival proportions of IAPP 7-19-TT or control-treated Tg or WT male mice (Figures 1 D–F) although both treated groups showed a trend for improved survival compared to their controls.

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