Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia.

Analysis of the mean time spent in the center of the open field showed a significant main effect for day, F(2, 138) = 7.09, p < 0.01, and a significant day × genotype interaction, F(6, 138) = 3.41, p < 0.01, while the main effect for genotype was close to significance, F(3, 69) = 2.47, p = 0.0692 (Figure 2C ).

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As shown in Figure 11 , while Aph1BC −/− mice spent more time in open areas than mice of the other genotypes on average, the genotype effect did not reach statistical significance, F(3, 60) = 1.396, p = 0.2527.

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Nevertheless, the time × genotype interaction approached significance, and when one-way ANOVA was performed on the percentage of freezing during the first, second, and third 1-min time periods separately, while no significant genotype effect was detected in the first minute, F(3, 53) = 2.47, p = 0.0720, or the second minute, F(3, 53) = 1.34, p = 0.2712, there was a significant genotype effect in the third minute, F(3, 53) = 3.25, p < 0.05.

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