Stereotactic radiosurgery (SRS) in the modern management of patients with brain metastases.

Oncotarget · 2016 · PMC4914287 · PMID 26848525

Europe PMC DOI

hedged sentences

0.0590

closest p · 1.2× alpha

0.0590

boldest claim

The sentences

a strong trendp = 0.059so close (0.05 < p ≤ 0.1)

Although the primary endpoint did not reach significance due to the high attrition rate, there was a strong trend ( p = 0.059) supporting memantine treatment.

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did not reach statistical significanceno p-value reported

The RCT evaluating SRS with WBRT alone, versus in combination with erlotinib or temozlomide, reported significantly greater Grade 3 to 5 toxicity rates in the combination arm; more importantly, survival was worse although it did not reach statistical significance [ 74 ].

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