Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.

Additionally, there was nominally borderline significance for a causal association between CRP and DBP after adjustment for heterogeneity.

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An observed p- value equal to or less than 0.05 was considered nominally significant evidence for a potential causal association, yet to be confirmed.

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The remaining outcomes tested for causal associations using GRS GWAS did not reach statistical significance, though the corresponding GRS GWAS proved to be a strong IV, with F -values ≥ 82 ( Table 3 ; S1 Fig ).

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