Sex-specific effects of cytotoxic chemotherapy agents cyclophosphamide and mitomycin C on gene expression, oxidative DNA damage, and epigenetic alterations in the prefrontal cortex and hippocampus - an aging connection.

Aging (Albany NY) · 2016 · PMC4925823 · PMID 27032448

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did not reach statistical significancep=0.146not close (p > 0.1)

a strong trendno p-value reported

Exposure to MMC led to a statistically significant increase in the 8-oxodG levels in the PFC tissues of male mice (p=0.016), while the PFCs of MMC-exposed female mice showed a strong trend towards an increase in 8-oxodG levels, but the difference did not reach statistical significance (p=0.146) (Figure 3 A ).

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