A meta-analysis of combination therapy versus single-agent therapy in anthracycline- and taxane-pretreated metastatic breast cancer: results from nine randomized Phase III trials.

Onco Targets Ther · 2016 · PMC4938138 · PMID 27445497

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failed to reach statistical significanceno p-value reported

Additionally, for other toxicities, the difference in hand-foot syndrome and toxic death between the doublets agents group and single-agent group failed to reach statistical significance ( Table 2 ).

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showed a trendno p-value reported

Moreover, unlike the previous study that showed a trend in favor of doublet agents with respect to OS, but the difference was not statistically significant partly due to the limited RCTs included, we demonstrated for the first time that doublet agents were more efficacious in terms of OS (HR 0.90, 95% CI 0.84–0.96, P =0.002), PFS (HR 0.81, 95% CI 0.76–0.88, P <0.001), and ORR (RR 1.72, 95% CI 1.34–2.21, P <0.001) when compared with single-agent therapy ( Figure 2A and B ) in the anthracyline- and taxane-pretreated breast cancer patients.

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