Chronic kidney disease and the risk of cancer: an individual patient data meta-analysis of 32,057 participants from six prospective studies.

BMC Cancer · 2016 · PMC4947287 · PMID 27421889

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0100

boldest claim

The sentences

a significant trendp = 0.01actually significant

There was also a significant trend towards an increased risk of other known/unknown cancers (trend p = 0.01), which appeared to be chiefly attributable to an increased risk of endocrine (mostly thyroid) cancers, with an increased risk of endocrine cancers among dialysis patients as compared to participants with eGFR ≥75 ml per min per 1.73 m 2 (adjusted HR 11.65, 95 % CI 1.30–104.12; Additional file 4 ).

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did not reach statistical significanceno p-value reported

In addition, dialysis patients had a twofold higher risk of death from cancers of the digestive tract (adjusted HR: 2.11; 95 % CI: 1.13–3.99), however the excess in digestive cancer incidence did not reach statistical significance (HR 1.51, 95 % CI 0.94–2.42).

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