Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity.

2A ) failed to reach statistical significance.

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In ARC, in line with the modest Ghsr deletion, expression of orexigenic neuropeptide Y (NPY) and agouti-related peptide (AgRP), as well as cannabinoid receptor type 1 (CB1), showed only a slight trend of decrease (not statistically significant), whereas anorexic pro-opiomelanocortin (POMC) was unchanged in Syn1 - Cre ; Ghsr f/f mice ( Fig. 4 C ).

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The fasting-induced rebound HFD feeding in young Syn1 - Cre ; Ghsr f/f mice showed a trend of increase within 2 h ( Fig. 2 B ).

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